XXVIth World Congress of the
International Society of Haematology
Singapore, 25-29 August, 1996
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CONTENTS
List of Authors
Plenary Lectures
Haemopoietic Stem Cell Transplantation
Quality Control
Chronic Myeloid Leukaemia and Myelodysplastic Syndromes
Vascular Biology
Red Cells
Molecular Biology: Applications
Lymphoma
Paediatric Haematology
Megakaryopoiesis
Transfusion Medicine
Thalassaemia
Coagulation
Myeloma and Chronic Lymphocytic Leukaemia
Acute Leukaemia
Stem Cell Processing
Immune Thrombocytopenia
Immunophenotyping and Flow Cytometry
Molecular Oncology and Cytogenetics
Bone Marrow Aplasia
Haemopoietic Growth Factors
Hypercoagulable States
Informatics in Haematology
Education and Training in Haematology
Morphology Review
Plenary Lectures
Prospects for Gene Therapy for Hematological and Neoplastic Disorders
Kan Yuet Wai
The Molecular Control of Granulocytes and Macrophages
Donald Metcalf
Molecular Pathogenesis of Paroxysmal Nocturnal Haemoglobinuria
Taroh Kinoshita
The Role of Recent Studies of the Molecular Pathology of the Thalassaemias in Their Control and Management
David Weatherall
Contents
Presidential Symposium: Haemopoietic Stem Cell Transplantation
A Brief Review of Bone Marrow Transplantation-1996
E. Donnall Thomas
Bone Marrow Transplantation in Thalassaemia: The Experience of Pesaro, Italy
Guido Lucarelli and Mariella Galimberti
Marrow Transplantation from Unrelated Volunteer Donors
Claudio Anasetti
Peripheral Blood Stem Cells: Transplantation and Beyond
L.B. To
Alternative Source of Stem Cells for Allogeneic Transplantation
E. Gluckman
Contents
ICSH Symposium: Quality Control
Quality Control: Good Laboratory Practice: An Overview of Quality Assurance
S.M. Lewis
MCHC:Red Cell Index or Quality Control Parameter?
Brian S. Bull, Raymond Aller, and Berend Houwen
Flagging Systems for Hematology Analyzers
John A. Koepke
The Control of Anticoagulant Therapy: Current Dilemmas
Eric Preston
Contents
Chronic Myeloid Leukaemia and Myelodysplastic Syndromes
Advances in Biology and Treatment of Chronic Myeloid Leukaemia
John M. Goldman
Treatment of Chronic Myelogenous Leukemia: Current Status and Investigational Options
Hagop M. Kantarjian, Susan O'Brien, Paolo Anderlini, and Moshe Talpaz
Morphology and Classification of the Myelodysplastic Syndromes and Their Pathologic Variants
Peter A. Kouides and John M. Bennett
Therapy for the Myelodysplastic Syndromes
Bruce D. Cheson
Contents
Vascular Biology
Lp(a) and the Microvasculature
Ralph L. Nachman
How Proteases Talk to Cells-Thrombin Receptor as a Paradigm
Shaun R. Coughlin
Leukocyte Adhesion to the Vasculature
John M. Harlan
Inside-Out Signaling in Integrins
Randall James Faull and Mark Howard Ginsberg
Contents
Red Cells
Red Cell Enzymopathies
Shiro Miwa
Lessons from the Molecular Biology of G6PD Deficiency
Ernest Beutler
Paroxysmal Nocturnal Haemoglobinuria (PNH
Lucio Luzzatto
Cobalamin and Folate Deficiency: The Antecedents and Associations
Ralph Green
Contents
Molecular Biology: Applications
Detection of Minimal Residual Disease in Acute Leukemia
Ching-Hon Pui and Dario Campana
MDR Genes in Leukemia
Victor Ling
Antenatal Screening
John Old
Molecular Biology: Applications in Transfusion Microbiology
John A.J. Barbara
Contents
Lymphoma
Intermediate and High Grade Non-Hodgkin's Lymphomas
Carol S. Portlock
Therapy for Low-Grade Non-Hodgkin's Lymphoma
Philip J. Bierman
Hodgkin's Disease
Ama Z.S. Rohatiner
Peripheral T-Cell Lymphoma
Raymond Liang
Contents
Paediatric Haematology
Acute Lymphocytic Leukemia in Children
Alvin M. Mauer
Acute Myeloid Leukaemia in Children
Ian M. Hann, Richard F. Stevens, Alan K. Burnett, Anthony H. Goldstone, Keith Wheatley, Richard G. Gray, and John H.K. Rees
Congenital Marrow Failure and Malignant Hematopoietic Transformation
Melvin H. Freedman
Pediatric Solid Tumors: Dose Intensity and Targeted Therapy
Nai-Kong V. Cheung
Contents
Megakaryopoiesis
Historical Overview of Megakaryocyte and Platelet Production
Martin J. Murphy Jr.
Structure/Function Relationships of Megakaryocytes and Platelets
Dorothea Zucker-Franklin
Thrombopoietin: Physiology and Preclinical Biology of the Primary Regulator of Megakaryocyte and Platelet Production
Kenneth Kaushansky
Contents
Transfusion Medicine
The Safety of the Blood Supply
Y.W. Ong and D. Teo
Clinically Significant Red Cell Antibodies Mediating Haemolytic Transfusion Reactions
Marcela Contreras
Current Applications of Therapeutic Hemapheresis
Alvaro A. Pineda
Risk Management in Transfusion Medicine: Maximising the Benefits and Minimising the Risks
James P. Isibister
Contents
Thalassaemia
Thalassaemia: Clinical Aspects and Screening
Prawase Wasi
Molecular Genetics of a-Thalassemia
Titus H.J. Huisman
Molecular Genetics of b-Thalassaemia
S.L. Thein
Oral Iron Chelation Therapy
A.V. Hoffbrand
Contents
Coagulation
Gene Therapy in Haemophilia
Ian Peake
Management of Hemophilia
Carol K. Kasper
Von Willebrand Disease and the Mechanisms of Platelet Function
Zaverio M. Ruggeri
Lupus Anticoagulants: A Protean Laboratory Phenomenon
Douglas A. Triplett
Contents
Myeloma and Chronic Lymphocytic Leukaemia
Multiple Myeloma: An Overview in 1996
Robert A. Kyle
Multiple Myeloma: Current Perspectives on Therapeutic Management
Sydney E. Salmon
Chronic Lymphocytic Leukaemia: An Overview
Kanti R. Rai
Treatment of Chronic Lymphocytic Leukemia
Lawrence D. Piro
Contents
Acute Leukaemia
Hematopoietic Growth Factors and Acute Myeloid Leukemia
B. Lowenberg
Acute Lymphoblastic Leukemia: Treatment
D. Hoelzer
Intensified Therapy for Acute Myeloid Leukaemia
James F. Bishop
Differentiation Therapy in Acute Promyelocytic Leukaemia
Zhen Yi Wang, Guan Lin Sun, Zhi Xiang Shen, Sai Juan Chen, and Zhu Chen
Contents
Stem Cell Processing
Overview of Peripheral Blood Stem Cell Collection and Storage
Scott D. Rowley
Cord Blood Transplantation and Biology
Hal E. Broxmeyer
Ex Vivo Expansion of Hematopoietic Progenitors
Tatsutoshi Nakahata
Transplantation of Allogeneic CD34+ Peripheral Blood Stem Cells
W.I. Bensinger and C.D. Buckner
Contents
Immune Thrombocytopenia
Platelet Glycoproteins
Michael C. Berndt, Robert K. Andrews, and Tracy McNally
Platelet Allo- and Autoantigens and Their Clinical Implications
Christian Mueller-Eckhardt
Drug-Induced Platelet Antibodies
B.H. Chong
Treatment of Autoimmune Thrombocytopenia
John G. Kelton
Contents
Immunophenotyping and Flow Cytometry
Overview of Human Leukocyte Differentiation Antigens
Hitoshi Kikutani
Immunophenotypic Analysis of Haematological Disorders
Wendy N. Erber
Clinical Applications of Multiparameter Flow Cytometry
Carleton C. Stewart
Detection of Apoptosis by Flow Cytometry
Zbigniew Darzynkiewicz
Contents
Molecular Oncology and Cytogenetics
Adult Acute Myeloid Leukemia Cytogenetics: Clinical and Biologic Significance
Clara D.Bloomfield, Kristiina Heinonen, and Krzysztof Mrozek
The Molecular Biology of Chronic Myeloid Leukaemia
L.C. Chan
Molecular Analysis of Chromosomal Abnormalities in Therapy-Related AML
Nanding Zhao, Rafael Espinosa III, and Michelle M. Le Beau
Molecular Analysis of Chromosome 11q23 Abnormalities in Leukaemia
Bryan D. Young
Contents
Bone Marrow Aplasia
The Pathophysiology of Acquired Aplastic Anemia
Neal S. Young
Epidemiology and Aetiology of Aplastic Anaemia
E.C. Gordon-Smith
Aplastic Anaemia: Treatment
Bruno Speck, Catherine Nissen, Andre Tichelli, and Alois Gratwohl
Aplastic Anaemia: Paediatric Aspects
Blanche P. Alter
Contents
Haemopoietic Growth Factors
The Biology of Haemopoiesis
Lynne Hampson, T. Michael Dexter, and Ian N. Hampson
Erythropoietin: Biology and Clinical Applications
Jerry L. Spivak
G-CSF and Myeloid Leukemias
Shigetaka Asano
GM-CSF: Biology and Appropriate Clinical Applications
Graham J. Lieschke
Contents
Hypercoagulable States
Antiphospholipid Syndrome and Thrombosis
Taneli Jouhikainen and Colin N. Chesterman
Hypercoagulability: An Updated Overview
A. Girolami, M.T. Sartori, G.M. Patrassi, B. Girolami, and M.A. Fadin
Resistance to Activated Protein C Caused by the R506Q Mutation in the Factor V Gene as a Basis of Venous Thrombosis
Bjorn DahlContents
Laboratory Markers of Coagulation Activation
Kenneth A. Bauer
Contents
Informatics in Haematology
Introduction to Information Science: Applications to the 26th ISH Congress
S.H. Lee
The American Society of Hematology Slide Bank
James R. McArthur and John R. Bolles
The Electronic Journal
Ernest Beutler and Earl B. Beutler
Cyberspace Hospital-An Information Resource for Haematologists on the Internet
K.C. Lun
Contents
Education and Training in Haematology
Education and Training in Haematology: The Asian Perspective
T.K. Chan
Education and Training in Haematology in Latin America
Guillermo J. Ruiz-Arguelles and Guillermo Ruiz-Reyes
Contents
