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CONTENTS

Plenary Lectures
Lectures
Seminars
Multiple Myeloma
Cord Blood Stem Cell Transplantation
Stem Cells
Standardization of Laboratory Medicine in Asia
Recent Progress in Hematopoietic Stem Cell Transplantation
Recent Advances in Pediatric Hematology
Malignant Lymphoma
Leukemia / Molecular and Cell Biology of Leukemia
Leukemia / Curative Strategy in Acute Leukemia
Aplastic Anemia / Myelodysplastic Syndrome
Hematomorphology Session


Plenary Lectures

Gene Therapy for ß-Thalassemia: Development of Therapeutically Consistent Gamma-Globin Lentiviral Vectors, In Vivo Selection of Genetically Modified Cells, and Testing in a Large Animal Model
Derek A. Persons

Treatment Of Hemophilia: The Present And The Future
Pier M. Mannucci

Paroxysmal Nocturnal Haemoglobinuria A pilgrimage of many steps
Edward C. Gordon-Smith

Contents
Lectures

Leukaemia Diagnosis 2004: The Integrated Final Report
Wendy N Erber

CML in the imatinib era
Kazunori Ohnishi

Autoimmune Thrombocytopenia
Beng H Chong

Stem Cell Biology for Angiogenesis
Takayuki Asahara

Contents
Seminars

New Therapeutic Approaches for Lymphoma and Chronic Lymphocytic Leukemia with Monoclonal Antibodies
Robert O. Dillman

The anti-coagulant therapy for septic organ dysfunction
Toshiaki Iba

Antisense therapy for Haematological Malignancies
Finbarr E Cotter

Update on the Management of Bleeding Disorders Using Activated Recombinant Factor VIIa
Harold R. Roberts

Basic aspects of human dendritic cell biology
Norimitsu Kadowaki

Role of antigen-presenting cells on graft-versus-host disease and graft-versus-tumor effects
Takanori Teshima

Haploidentical Transplantation in Children: Update and further Prospects
R.Handgretinger, E.Benaim, G.Hale W.Leung

The effect of argatroban on the function of vascular endothelial cells stimulated by bound thrombin
T. Kosugi, K. Kinjoh, M. Sunagawa, M. Nakamura

An Update on Argatroban Anticoagulant Therapy
Jawed Fareed

Current Management of the Febrile Neutropenic Patient
Kenneth V. I. Rolston

Disseminated Intravascular Coagulation
Marcel Levi

Contents
Multiple Myeloma

Gene Expression Profiling To Model Prognosis of Myeloma Treated with Tandem Auto Transplants
John Shaughnessy, Fenghuang Zhan, Erik Rasmussen, Bart Barlogie

The biological meaning of heterogeneous expression of CD45 on human myeloma cells
Michio M. Kawano

Multistep tumorigenesis of multiple myeloma: Its molecular delineation
Shinsuke Iida

A bone disease in multiple myeloma: cellular interplay in the myeloma bone microenvironment
Masahiro Abe

Novel Targeted Therapies for Multiple Myeloma
Nikhil C. Munshi

Hematopoetic Stem Cell Transplantation for the Treatment of Multiple Myeloma
William I. Bensinger

Contents
Cord Blood Stem Cell Transplantation

Umbilical Cord Blood Transplantation in Europe
Guillermo F. Sanz, Vanderson Rocha, William Arcese, Gerard Michel, Franco Locatelli, Myriam Labopin, Eliane Gluckman, for the Eurocord Registry

Isolation and characterization of mesenchymal stem/progenitor cells from chorionic villi of human placenta
Tsuneo A Takahashi, Kouichi Igura, XiaoHong Zhang, Kenji Takahashi, Yuka Mori, Ayako Mitsuru, Hitomi Nagayama

Approaches for inducing immunotolerance in clinical mismatched haploidentical hematopoietic stem cell transplant (HSCT)
DP Lu, W Hang, XJ Wang, H Chen, YH Chen, LJ Tong, T Wu, NL Guo, KY Liu

CBSCT in Japan
Shunichi Kato, Koji Kato, Keiichi Isoyama, Hirokazu Nishihira, Hiroshi Hara, Tohru Iseki, Shigesaburo Miyakoshi, Hidehiko Saito

Contents
Stem Cells

Human Embryonic Stem Cells: The First Five Years
Martin F. Pera, Andrew Laslett, Alice Pebay, Susan Hawes, Ernst Wolvetang, Mirella Dottori.

Stem Cell Gene Therapy
Derek A. Persons

Adult Stem Cell Research and Translational Studies for Reparative Medicine
Yao-Chang Chen

Ex vivo expansion of human hematopoietic stem cells
Kiyoshi Ando

Contents
Standardization of Laboratory Medicine in Asia

Problems in the Diagnosis of Anemia
Oytip Nathalang

Hemoglobin Color Scale and Peripheral blood smears as a tool to detect anemia and some hematologic abnormalities in peripheral laboratories
Ina S. Timan, Diana Aulia

Report of Asian Quality Assurance Survey program (AQuAS) on laboratory hematology
Kap No Lee, Soo-Young Yoon, Han-Ik Cho, Noriyuki Tatsumi, Tomas Maramba, Jr

Current problems in standardization of hematological examinations in Japan
Noriyuki Tatsumi, Kiyoaki Watanabe

Contents
Recent Progress in Hematopoietic Stem Cell Transplantation

Human Minor Histocompatibility Antigens: Targets of Graft-versus-Host Disease and Graft-versus-Leukemia Responses
Makoto Murata

Reduced Intensity Allogeneic Stem Cell Transplantation for Hematologic Malignancies
Richard Champlin, Sergio Giralt, Paolo Anderlini, Issa Khouri

Reduced-Intensity Stem Cell Transplantation (RIST): A Japanese Experience
Yoichi Takaue

Insight Into The Graft Versus Solid Tumor Effect: Efforts To Move From Proof Of Concept To More Effective Allogeneic NK And T-Cell Based Allogeneic Immunotherapy
Richard W. Childs

Contents
Recent Advances in Pediatric Hematology

Hematopoietic stem cell transplantation in childhood acute lymphoblastic leukemia in Japan. From the Registry of Japanese Society of Pediatric Hematology
Masahiro Tsuchida

Hematopoietic Stem Cell Transplantation
Kyung-Ha Ryu

Aplastic Anemia in Korea
Dae Chul Jeong

Aplastic anemia; epidemiology and clinical trial in Japan
Akira Ohara

A prospective registration of children with myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD) in Japan
Atsushi Manabe1, Masahiro Tsuchida2, Atsuko Masunaga3, Tatsutoshi Nakahata4

Melodysplastic syndrome in Korean children: Clinical findings and application of prognostic scoring systems
Hoon Kook

Idiopathic Thrombocytopenic Purpura
Hee Young Shin

Current diagnostic and management strategy for childhood idiopathic thrombocytopenic purpura in Japan
Kohji Fujisawa

Contents
Malignant Lymphoma

WHO Classification of Lymphoid Neoplasm -A goal, or a new starting point?
Shigeo Mori

Chromosomal abnormalities in lymphoma pathogenesis and their clinical significance
Masafumi Taniwaki

Lymphoma Trials in low grade and high grade lymphomas in Germany - Results of prospective randomized trials support the use of chemo-immunotherapy and define the role of front-up dose escalation strategies
Lorenz H. Trümper

Treating B cell aggressive lymphomas in clinical trials, present and future: The GELA experience
Christian Gisselbrecht

Contents
Leukemia / Molecular and Cell Biology of Leukemia

Human Leukemia Stem Cells
John E. Dick

The Emerging Genetics of T-cell Acute Lymphoblastic Leukemia: a Fish Tale
A. Thomas Look

Oncogenic FLT3 as an important target for acute myeloid leukemia: beyond ATRA and imatinib
Tomoki Naoe

Contents
Leukemia / Curative Strategy in Acute Leukemia

Therapy of Acute Myeloid Leukemia: Past Achievements and Future Directions of the Eastern Cooperative Oncology Group (ECOG)
Martin S. Tallman

Treatment of Acute Promyelocytic Leukemia: 18-year experience of single institute
Jiong Hu, Zhixiang Shen, Guanlin Sun, Saijuan Chen, Zhenyi Wang, Zu Chen

Therapies to Acute Myelogeous Leukemia in JAPAN ADULT LEUKEMIA STUDY GROUP (JALSG)
Hisashi Sakamaki

Contents
Aplastic Anemia / Myelodysplastic Syndrome

Recent advances in the treatment of severe aplastic anemia
Andrea Bacigalupo

Aplastic Anemia in Children
Seiji Kojima

Pediatric MDS
Charlotte M. Niemeyer

Biology of Myelodysplastic Syndromes.
Kazuma Ohyashiki

Contents
Hematomorphology Session

Hematomorphology Cases 1-8 (3.3MB)
Hematomorphology Cases 9-16 (5.5MB)
Hematomorphology Cases 17-28 (4.8MB)
Szu-Hee Lee, Wendy Erber, Yataro Yoshida, Masao Tomonaga

Contents